Nanofibers for drug delivery – incorporation and release of model molecules, influence of molecular weight and polymer structure

• Jakub Hrib,
• Jakub Sirc,
• Radka Hobzova,
• Zuzana Hampejsova,
• Zuzana Bosakova,
• Marcela Munzarova and
• Jiri Michalek

Beilstein J. Nanotechnol. 2015, 6, 1939–1945, doi:10.3762/bjnano.6.198

• ; nanofibrous carriers; needle-free electrospinning; release kinetics; Introduction To date, numerous drug delivery systems have been developed, such as hydrogels that carry drugs or highly sophisticated electronic microchips [1][2]. The required release rates of the therapeutic agents depend on the medicinal

• amount positively correlated with molecular weight of the incorporated molecules. This trend was observed for all of the prepared nanofibrous carriers. The strongest effect appeared for PVA fibers containing hydroxy functional groups, i.e., 90% of PEG 20 model molecules released within 72 h. These

• . Morphological characterization of nanofibrous carriers. Acknowledgement The financial support of the Ministry of Education, Youth and Sports of the Czech Republic (grant No. EE2.3.30.0029), the Grant Agency of the Czech Republic (grant No. 13-00939S), the Charles University in Prague (project no. 307115 and